According to alternative medicine practitioners, candida depression occurs when toxic Candida byproducts enter the bloodstream and affect the brain.

 Proponents of candidiasis depression make claims that  yeast toxin hypersensitivity has a number of negative neurological effects. Some of those effects are: depression, memory issues, anxiety and a problem with ones reasoning ability.

Another hypothesis why Candida can cause depression is the reduction of magnesium absorption from the intestine when there is a Candida overgrowth in the gut. Magnesium deficiency is implicated as one of the possible causes for depression.

While allopathic medicine supports an indirect link between depression and Candida Albicans, holistic, or alternative practitioners believe the link is direct.

It is believed that depression caused by candida does not respond to allopathic prescription medications. In order to relieve the depression the candida needs to be controlled and minimized by detoxification, herbs, garlic and by eating a diet designed to reduce the overgrowth of the candida.  Learning to reduce stress levels, and to improve ones mental outlook and level of positivity is also part of the program.